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Description: Menopause is the cessation of the ovarian follicular activity followed by the termination of the menstrual cycle. The age of menopause varies in different societies, but on average, it occurs between 48 and 52 years old. The incidence and severity of menopausal symptoms vary between women and are affected by various factors such as genetics, environment, anthropometrics, lifestyle, and race. Early menopause is associated with an increased risk of osteoporosis, coronary artery disease, stroke, and death. These factors can affect women's health and quality of life. However, one of the most critical symptoms of these patients is the symptoms related to metabolic disorders. Menopause can lead to increased total body fat and body fat distribution from the periphery to the trunk, resulting in visceral obesity. Abdominal obesity and estrogen reduction during menopause are associated with adverse metabolic changes such as insulin resistance, tendency to develop type 2 diabetes, and dyslipidemia. Due to the increase in the prevalence and occurrence of type 2 diabetes in recent decades, paying attention to possible risk factors of this disease has become very important. The rate of Disability-Adjusted Life Years (DALYs) for women with T2DM increased by 34.2% from 2007 to 2017. Moreover, at least one of the T2DM risk factors, including hypertension (HTN), dyslipidemia, central obesity, and increased fasting glucose level, occurs in 50-80% of menopausal women. Therefore, identifying potential risk factors for T2DM, such as menopause, is critical for early detection, prevention, and management. However, few studies have investigated the effect of menopause on the probability of type 2 diabetes. The results of these studies conflict with each other. For example, some studies point to an increase in the likelihood of type 2 diabetes with a decrease in the age of menopause[15, 16]. However, others deny the existence of a relationship between the two[17, 18]. Therefore, in this systematic review and meta-analysis, we will analyze the available studies on the relationship between the age of menopause and the risk of type 2 diabetes. Method: We will search online databases with related keywords, including PubMed, Scopus, and Google Scholar. The two reviewers will perform study selection based on inclusion criteria. Inclusion criteria are 1) study design, prospective cohort, cross-sectional studies, case-control, and randomized controlled trials (RCTs). 2) Participants were postmenopausal women (women who experienced natural or surgical menopause) without a history of type 2 diabetes at baseline. 3) Reporting age of menopause, 4) Type 2 diabetes diagnosis confirmed through clinical or laboratory criteria. 5) Studies should report sufficient data to calculate odds ratios (OR) and 95% confidence intervals (95%CI) for the association between age at menopause and type 2 diabetes mellitus (T2DM). Two separate reviewers will extract data, including the author's name, year, type of study, sample size, age at menopause, and number of T2DM in each category of menopausal age. Statistical analysis will be performed by calculating the pooled effect size and 95% CI of included studies using the random effect model and the DerSimonian-Laird method. Publication bias will be assessed through a Funnel plot and Egger's test.