Americans disagree about many things, including what threats are most pressing. We suggest people morally condemn and dehumanize opponents when they are perceived as rejecting the existence or severity of important perceived threats. We explore perceived “threat rejection” across five studies (N=2,404) both in the real-world COVID-19 pandemic and in novel contexts. Americans morally condemned and dehumanized policy opponents when they seemed to reject realistic group threats (e.g., threat to the physical health or resources of the group). Believing opponents rejected symbolic group threats (e.g., to collective identity) was not reliably linked to condemnation and dehumanization. Importantly, the political dehumanization caused by perceived threat rejection can be soothed with a “threat acknowledgement” intervention.