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The replication of Study 38: [Schepers et al., 2012][1] was [not pursued][2]; however, this project contains all information pertaining to the attempted replication of key experiments from this paper. It includes the detailed protocols, including reagents and author clarifications where they are available. **Original citation:** Schepers A.G., Snippert H.J., Stange D.E., Van Den Born M., Van Es J.H., Van De Wetering M., Clevers H. Lineage Tracing Reveals Lgr5(+) Stem Cell Activity in Mouse Intestinal Adenomas. Science. 2012 Aug 10;337(6095):730-5. doi: 10.1126/science.1224676. ---------- Note: This study has been cut from the Reproducibility Project: Cancer Biology due to feasibility constraints in generating the mouse model. [1]: http://science.sciencemag.org/content/337/6095/730 [2]: https://osf.io/ucpye/
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