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Category: Project

Description: Early detection of cardiotoxic symptoms during chemotherapy is vital for cancer patients' survival and quality of life. The Project idea is to elaborate an algorithm to prevent cardiotoxic complications during chemotherapy. Among methods of evaluating heart activity, assessment of global longitudinal myocardial strain (GLS) is the most effective as being the earliest, although quite expensive. On the contrary, cardiac markers are the most cost-effective. Therefore, the need is raised to determine the predictive value of biomarkers of damage, inflammation, etc., by assessing global longitudinal myocardial strain in chemotherapy patients. Detecting incipient stages of cardiotoxicity in Breast cancer patients using relatively cheap and the earliest responding biomarkers would allow the development of a cost-effective algorithm for timely correction of the chemotherapy cardiotoxic effects. Thus, the essence of the project is to find correlations between the decrease in systolic myocardial function recorded by echocardiography, including speckle tracking, and the values of the mentioned biomarkers.