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Reducing the harmful effects of cannabis use: Finding the optimal CBD:THC ratio
- Amir Englund
- Dominic Oliver
- Edward Chesney
- Jack Wilson
- Lucy Chester
- Simina Sovi
- Tom Freeman
- John Hodsoll
- Robin Murray
- Philip McGuire
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Description: The aim of this experimental study is to determine which ratio of CBD:THC is related to the least adverse effects (psychosis, cognitive impairment) while still retaining its pleasurable and rewarding effects. This will be measured using standardised cognitive and psychological/psychopathological measures. The study will also aim to explore if these differences are explained by the ratio of CBD:THC in the cannabis or by pharmacodynamics (e.g. CBD reducing blood THC levels). This will be explored by collecting blood samples from the participants following cannabis administration.
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